Thalidomide for treatment of multiple myeloma : 10 years later
Identifieur interne : 008996 ( Main/Exploration ); précédent : 008995; suivant : 008997Thalidomide for treatment of multiple myeloma : 10 years later
Auteurs : Antonio Palumbo [Italie] ; Thierry Facon [France] ; Pieter Sonneveld [Pays-Bas] ; Joan Blade [Espagne] ; Massimo Offidani [Italie] ; Francesca Gay [Italie] ; Philippe Moreau [France] ; Anders Waage [Norvège] ; Andrew Spencer [Australie] ; Heinz Ludwig [Autriche] ; Mario Boccadoro [Italie] ; Jean-Luc Harousseau [France]Source :
- Blood [ 0006-4971 ] ; 2008.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Thalidomide, bortezomib, and lenalidomide have recently changed the treatment paradigm of myeloma. In young, newly diagnosed patients, the combination of thalidomide and dexamethasone has been widely used as induction treatment before autologous stem cell transplantation (ASCT). In 2 randomized studies, consolidation or maintenance with low-dose thalidomide has extended both progression-free and overall survival in patients who underwent ASCT at diagnosis. In elderly, newly diagnosed patients, 3 independent randomized studies have reported that the oral combination of melphalan and prednisone plus thalidomide (MPT) is better than the standard melphaIan and prednisone (MP). These studies have shown better progression-free survival, and 2 have shown improved overall survival for patients assigned to MPT. In refractory-relapsed disease, combinations including thalidomide with dexamethasone, melphalan, doxorubicin, or cyclophosphamide have been extensively investigated. The risks of side effects are greater when thalidomide is used in combination with other drugs. Thromboembolism and peripheral neuropathy are the major concern. The introduction of anticoagulant prophylaxis has reduced the rate of thromboembolism to less than 10%. Immediate thalidomide dose reduction or discontinuation when paresthesia is complicated by pain or motor deficit has decreased the severity of neuropathy. Future studies will define the most effective or the best sequence of combinations which could improve life expectancy.
Affiliations:
- Australie, Autriche, Espagne, France, Italie, Norvège, Pays-Bas
- Catalogne, Hauts-de-France, Hollande-Méridionale, Nord-Pas-de-Calais, Pays de la Loire, Piémont, Trøndelag, Victoria (État), Vienne (Autriche)
- Barcelone, Lille, Melbourne, Nantes, Rotterdam, Trondheim, Turin, Vienne (Autriche)
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 003465
- to stream PascalFrancis, to step Curation: 002B84
- to stream PascalFrancis, to step Checkpoint: 002E58
- to stream Main, to step Merge: 009272
- to stream Main, to step Curation: 008996
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Thalidomide for treatment of multiple myeloma : 10 years later</title><author><name sortKey="Palumbo, Antonio" sort="Palumbo, Antonio" uniqKey="Palumbo A" first="Antonio" last="Palumbo">Antonio Palumbo</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Division of Hematology, University of Torino, Azienda Ospedaliera S Giovanni Battista</s1><s2>Torino</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Facon, Thierry" sort="Facon, Thierry" uniqKey="Facon T" first="Thierry" last="Facon">Thierry Facon</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>University of Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>2 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Sonneveld, Pieter" sort="Sonneveld, Pieter" uniqKey="Sonneveld P" first="Pieter" last="Sonneveld">Pieter Sonneveld</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>3 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Blade, Joan" sort="Blade, Joan" uniqKey="Blade J" first="Joan" last="Blade">Joan Blade</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Hematology Department, Hospital Clinic, Institut d'lnvestigacions Biomèdiques August Pi I Sunyer (IDIBAPS)</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>4 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Offidani, Massimo" sort="Offidani, Massimo" uniqKey="Offidani M" first="Massimo" last="Offidani">Massimo Offidani</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Hematology Clinic, University of Ancona</s1><s2>Ancona</s2><s3>ITA</s3><sZ>5 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Ancona</wicri:noRegion></affiliation></author><author><name sortKey="Gay, Francesca" sort="Gay, Francesca" uniqKey="Gay F" first="Francesca" last="Gay">Francesca Gay</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Division of Hematology, University of Torino, Azienda Ospedaliera S Giovanni Battista</s1><s2>Torino</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Moreau, Philippe" sort="Moreau, Philippe" uniqKey="Moreau P" first="Philippe" last="Moreau">Philippe Moreau</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Hematology Department, University Hospital</s1><s2>Nantes</s2><s3>FRA</s3><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Waage, Anders" sort="Waage, Anders" uniqKey="Waage A" first="Anders" last="Waage">Anders Waage</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Haematology, University Hospital Trondheim</s1><s2>Trondheim</s2><s3>NOR</s3><sZ>8 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Spencer, Andrew" sort="Spencer, Andrew" uniqKey="Spencer A" first="Andrew" last="Spencer">Andrew Spencer</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Clinical Haematology and BMT, The Alfred Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Ludwig, Heinz" sort="Ludwig, Heinz" uniqKey="Ludwig H" first="Heinz" last="Ludwig">Heinz Ludwig</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>First Department of Medicine, Center for Oncology and Haematology, Wilhelminenspital</s1><s2>Vienna</s2><s3>AUT</s3><sZ>10 aut.</sZ></inist:fA14><country>Autriche</country><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Boccadoro, Mario" sort="Boccadoro, Mario" uniqKey="Boccadoro M" first="Mario" last="Boccadoro">Mario Boccadoro</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Division of Hematology, University of Torino, Azienda Ospedaliera S Giovanni Battista</s1><s2>Torino</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Harousseau, Jean Luc" sort="Harousseau, Jean Luc" uniqKey="Harousseau J" first="Jean-Luc" last="Harousseau">Jean-Luc Harousseau</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Hôspital Hotel-Dieu</s1><s2>Nantes</s2><s3>FRA</s3><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">08-0314257</idno><date when="2008">2008</date><idno type="stanalyst">PASCAL 08-0314257 INIST</idno><idno type="RBID">Pascal:08-0314257</idno><idno type="wicri:Area/PascalFrancis/Corpus">003465</idno><idno type="wicri:Area/PascalFrancis/Curation">002B84</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002E58</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">002E58</idno><idno type="wicri:doubleKey">0006-4971:2008:Palumbo A:thalidomide:for:treatment</idno><idno type="wicri:Area/Main/Merge">009272</idno><idno type="wicri:Area/Main/Curation">008996</idno><idno type="wicri:Area/Main/Exploration">008996</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Thalidomide for treatment of multiple myeloma : 10 years later</title><author><name sortKey="Palumbo, Antonio" sort="Palumbo, Antonio" uniqKey="Palumbo A" first="Antonio" last="Palumbo">Antonio Palumbo</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Division of Hematology, University of Torino, Azienda Ospedaliera S Giovanni Battista</s1><s2>Torino</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Facon, Thierry" sort="Facon, Thierry" uniqKey="Facon T" first="Thierry" last="Facon">Thierry Facon</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>University of Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>2 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Sonneveld, Pieter" sort="Sonneveld, Pieter" uniqKey="Sonneveld P" first="Pieter" last="Sonneveld">Pieter Sonneveld</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>3 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Blade, Joan" sort="Blade, Joan" uniqKey="Blade J" first="Joan" last="Blade">Joan Blade</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Hematology Department, Hospital Clinic, Institut d'lnvestigacions Biomèdiques August Pi I Sunyer (IDIBAPS)</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>4 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Offidani, Massimo" sort="Offidani, Massimo" uniqKey="Offidani M" first="Massimo" last="Offidani">Massimo Offidani</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Hematology Clinic, University of Ancona</s1><s2>Ancona</s2><s3>ITA</s3><sZ>5 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Ancona</wicri:noRegion></affiliation></author><author><name sortKey="Gay, Francesca" sort="Gay, Francesca" uniqKey="Gay F" first="Francesca" last="Gay">Francesca Gay</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Division of Hematology, University of Torino, Azienda Ospedaliera S Giovanni Battista</s1><s2>Torino</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Moreau, Philippe" sort="Moreau, Philippe" uniqKey="Moreau P" first="Philippe" last="Moreau">Philippe Moreau</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Hematology Department, University Hospital</s1><s2>Nantes</s2><s3>FRA</s3><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Waage, Anders" sort="Waage, Anders" uniqKey="Waage A" first="Anders" last="Waage">Anders Waage</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Haematology, University Hospital Trondheim</s1><s2>Trondheim</s2><s3>NOR</s3><sZ>8 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Spencer, Andrew" sort="Spencer, Andrew" uniqKey="Spencer A" first="Andrew" last="Spencer">Andrew Spencer</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Clinical Haematology and BMT, The Alfred Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Ludwig, Heinz" sort="Ludwig, Heinz" uniqKey="Ludwig H" first="Heinz" last="Ludwig">Heinz Ludwig</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>First Department of Medicine, Center for Oncology and Haematology, Wilhelminenspital</s1><s2>Vienna</s2><s3>AUT</s3><sZ>10 aut.</sZ></inist:fA14><country>Autriche</country><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Boccadoro, Mario" sort="Boccadoro, Mario" uniqKey="Boccadoro M" first="Mario" last="Boccadoro">Mario Boccadoro</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Division of Hematology, University of Torino, Azienda Ospedaliera S Giovanni Battista</s1><s2>Torino</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Harousseau, Jean Luc" sort="Harousseau, Jean Luc" uniqKey="Harousseau J" first="Jean-Luc" last="Harousseau">Jean-Luc Harousseau</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Hôspital Hotel-Dieu</s1><s2>Nantes</s2><s3>FRA</s3><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Blood</title><title level="j" type="abbreviated">Blood</title><idno type="ISSN">0006-4971</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Blood</title><title level="j" type="abbreviated">Blood</title><idno type="ISSN">0006-4971</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antineoplastic agent</term><term>Hematology</term><term>Myeloma</term><term>Thalidomide</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Thalidomide</term><term>Traitement</term><term>Hématologie</term><term>Myélome</term><term>Anticancéreux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Thalidomide, bortezomib, and lenalidomide have recently changed the treatment paradigm of myeloma. In young, newly diagnosed patients, the combination of thalidomide and dexamethasone has been widely used as induction treatment before autologous stem cell transplantation (ASCT). In 2 randomized studies, consolidation or maintenance with low-dose thalidomide has extended both progression-free and overall survival in patients who underwent ASCT at diagnosis. In elderly, newly diagnosed patients, 3 independent randomized studies have reported that the oral combination of melphalan and prednisone plus thalidomide (MPT) is better than the standard melphaIan and prednisone (MP). These studies have shown better progression-free survival, and 2 have shown improved overall survival for patients assigned to MPT. In refractory-relapsed disease, combinations including thalidomide with dexamethasone, melphalan, doxorubicin, or cyclophosphamide have been extensively investigated. The risks of side effects are greater when thalidomide is used in combination with other drugs. Thromboembolism and peripheral neuropathy are the major concern. The introduction of anticoagulant prophylaxis has reduced the rate of thromboembolism to less than 10%. Immediate thalidomide dose reduction or discontinuation when paresthesia is complicated by pain or motor deficit has decreased the severity of neuropathy. Future studies will define the most effective or the best sequence of combinations which could improve life expectancy.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Autriche</li><li>Espagne</li><li>France</li><li>Italie</li><li>Norvège</li><li>Pays-Bas</li></country><region><li>Catalogne</li><li>Hauts-de-France</li><li>Hollande-Méridionale</li><li>Nord-Pas-de-Calais</li><li>Pays de la Loire</li><li>Piémont</li><li>Trøndelag</li><li>Victoria (État)</li><li>Vienne (Autriche)</li></region><settlement><li>Barcelone</li><li>Lille</li><li>Melbourne</li><li>Nantes</li><li>Rotterdam</li><li>Trondheim</li><li>Turin</li><li>Vienne (Autriche)</li></settlement></list><tree><country name="Italie"><region name="Piémont"><name sortKey="Palumbo, Antonio" sort="Palumbo, Antonio" uniqKey="Palumbo A" first="Antonio" last="Palumbo">Antonio Palumbo</name></region><name sortKey="Boccadoro, Mario" sort="Boccadoro, Mario" uniqKey="Boccadoro M" first="Mario" last="Boccadoro">Mario Boccadoro</name><name sortKey="Gay, Francesca" sort="Gay, Francesca" uniqKey="Gay F" first="Francesca" last="Gay">Francesca Gay</name><name sortKey="Offidani, Massimo" sort="Offidani, Massimo" uniqKey="Offidani M" first="Massimo" last="Offidani">Massimo Offidani</name></country><country name="France"><region name="Hauts-de-France"><name sortKey="Facon, Thierry" sort="Facon, Thierry" uniqKey="Facon T" first="Thierry" last="Facon">Thierry Facon</name></region><name sortKey="Harousseau, Jean Luc" sort="Harousseau, Jean Luc" uniqKey="Harousseau J" first="Jean-Luc" last="Harousseau">Jean-Luc Harousseau</name><name sortKey="Moreau, Philippe" sort="Moreau, Philippe" uniqKey="Moreau P" first="Philippe" last="Moreau">Philippe Moreau</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Sonneveld, Pieter" sort="Sonneveld, Pieter" uniqKey="Sonneveld P" first="Pieter" last="Sonneveld">Pieter Sonneveld</name></region></country><country name="Espagne"><region name="Catalogne"><name sortKey="Blade, Joan" sort="Blade, Joan" uniqKey="Blade J" first="Joan" last="Blade">Joan Blade</name></region></country><country name="Norvège"><region name="Trøndelag"><name sortKey="Waage, Anders" sort="Waage, Anders" uniqKey="Waage A" first="Anders" last="Waage">Anders Waage</name></region></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Spencer, Andrew" sort="Spencer, Andrew" uniqKey="Spencer A" first="Andrew" last="Spencer">Andrew Spencer</name></region></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Ludwig, Heinz" sort="Ludwig, Heinz" uniqKey="Ludwig H" first="Heinz" last="Ludwig">Heinz Ludwig</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 008996 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 008996 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:08-0314257
|texte= Thalidomide for treatment of multiple myeloma : 10 years later
}}
| This area was generated with Dilib version V0.6.33. |  |